Shellfish allergy - Diagnosis and treatment (2024)

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Diagnosis

Positive reaction to allergy test

Shellfish allergy - Diagnosis and treatment (1)

Positive reaction to allergy test

A small area of swelling with surrounding redness is typical of a positive allergy skin test.

To find out if you have shellfish allergy, your health care provider will ask about your symptoms and do a physical exam to find or rule out other medical problems.

A history of allergic reactions shortly after exposure to shellfish can be a sign of shellfish allergy. But the symptoms could also be caused by something else, such as food poisoning.

Allergy testing is the only sure way to tell what's causing your symptoms, so your provider may recommend one or both of these tests:

  • Skin prick test. Small amounts of the proteins found in shellfish are pricked into skin on your arm or upper back. You're then watched for an allergic reaction. If you're allergic, you'll develop a raised bump (hive) at the test site on your skin. This typically takes about 15 to 20 minutes. Allergy specialists usually are best equipped to perform allergy skin tests.
  • Blood test. A blood sample is sent to a lab to measure your immune system's response to a specific allergen. This test measures your immune system's response to shellfish proteins by measuring the amount of allergy-causing antibodies in your bloodstream, known as immunoglobulin E (IgE) antibodies.

Medically supervised food challenges can be performed if the diagnosis still isn't clear after allergy testing.

More Information

  • Allergy skin tests

Treatment

The only sure way to prevent an allergic reaction to shellfish is to avoid shellfish. But despite your best efforts, you may come into contact with shellfish.

If you have a severe allergic reaction to shellfish (anaphylaxis), you'll likely need an emergency injection of epinephrine (adrenaline). If you're at risk of anaphylaxis to shellfish, your health care provider can give you a prescription in advance and explain how and when to give the injection. Regularly check the expiration date on the packaging to make sure it's current.

Carry injectable epinephrine (Auvi-Q, EpiPen, others) with you at all times. Epinephrine is typically given at the first sign of an allergic reaction. A second dose may be needed if symptoms recur. After you use epinephrine, seek emergency medical care, even if you start to feel better.

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Preparing for your appointment

You're likely to start by seeing your family health care provider. Or you may be referred directly to an allergy specialist.

What you can do

Prepare for your appointment by making a list of:

  • Symptoms, including any that may seem unrelated to an allergy
  • Family history of allergies and asthma, including specific types of allergies if you know them
  • Medications, vitamins, herbs or other supplements you're taking, and the dosages
  • Questions to ask your health care provider

Questions related to shellfish allergy include:

  • Are my symptoms most likely due to an allergy?
  • Will I need any allergy tests?
  • Should I see an allergist?
  • Do I need to carry epinephrine?
  • Are there brochures or other educational materials I can have? What websites do you recommend?

Don't hesitate to ask other questions, as well.

What to expect from your doctor

Your health care provider may ask you questions, such as:

  • What symptoms are you having? How severe are they?
  • When did you notice your symptoms?
  • Have you reacted to shellfish in the past?
  • What kind of shellfish did you eat?
  • How soon after eating shellfish did your symptoms occur?
  • What other foods did you eat during your meal? Don't forget sauces, beverages and side dishes.
  • Did others who dined with you have similar symptoms?
  • Is there a history of allergy in your family?
  • Do you have other allergies, such as hay fever?
  • Do you have asthma or eczema (atopic dermatitis)?

What you can do in the meantime

Avoid eating or touching any type of shellfish while waiting for your appointment.

By Mayo Clinic Staff

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Aug. 05, 2022

Print

  1. Shellfish. American College of Allergy, Asthma and Immunology. https://acaai.org/allergies/allergic-conditions/food/shellfish/. Accessed April 27, 2022.
  2. Shaker MS, et al. Anaphylaxis — A 2020 practice parameter update, systematic review, and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) analysis. Journal of Allergy and Clinical Immunology. 2020; doi:10.1016/j.jaci.2020.01.017.
  3. Anaphylaxis. American Academy of Allergy, Asthma & Immunology. https://acaai.org/allergies/symptoms/anaphylaxis/. Accessed April 27, 2022.
  4. Sicherer SH. Seafood allergies: Fish and shellfish. https://www.uptodate.com/contents/search. Accessed April 27, 2022.
  5. Cameron P, et al., eds. Computed tomography scanning in emergency medicine. In: Textbook of Adult Emergency Medicine. 5th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed April 27, 2022.
  6. Ruethers T, et al. Seafood allergy: A comprehensive review of fish and shellfish allergens. Molecular Immunology. 2018; doi:10.1016/j.molimm.2018.04.008.
  7. Wong L, et al. An update on shellfish allergy. Current Opinion in Allergy and Clinical Immunology. 2019; doi:10.1097/ACI.0000000000000532.
  8. Li JTC (expert opinion). Mayo Clinic. May 4, 2022.

Related

Associated Procedures

  • Allergy skin tests

Shellfish allergy

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Shellfish allergy - Diagnosis and treatment (2024)

FAQs

What is the treatment for shellfish allergy? ›

If you have a severe allergic reaction to shellfish (anaphylaxis), you'll likely need an emergency injection of epinephrine (adrenaline). If you're at risk of anaphylaxis to shellfish, your health care provider can give you a prescription in advance and explain how and when to give the injection.

How do you diagnose a shellfish allergy? ›

To diagnose shellfish allergy, the routine workup would involve a thorough review of the patient's history, a skin prick test, and a blood test for shellfish allergens and tropomyosin. Clinicians would then assess whether an oral food challenge is necessary to confirm a diagnosis.

Will my shellfish allergy ever go away? ›

Most people who have a shellfish allergy have it for life. It doesn't go away over time.

What is the most common allergic reaction to shellfish? ›

Symptoms of fish or shellfish allergies vary and range from mild reactions to a severe allergic reaction (anaphylaxis). The most common symptom is raised red bumps of skin (hives). Other symptoms include wheezing and trouble breathing, cramps, nausea or vomiting.

Why do I suddenly have shellfish allergy? ›

An allergy to shellfish may develop any time during a person's life, but tends to present in adulthood. It can be caused by foods that you've eaten before with no issues. Along with fish, shellfish allergies are the most common adult-onset food allergies.

What antihistamine is good for shellfish allergy? ›

During a mild reaction

Take a non-drowsy antihistamine, such as loratadine (Claritin), as your doctor recommends. Be safe with medicines. Read and follow all instructions on the label.

How fast does a shellfish allergy start? ›

Shellfish allergy symptoms generally start within minutes to an hour after eating or having contact with shellfish. They may include: Hives. Itchy, irritated skin.

What to avoid if you have a shellfish allergy? ›

Don't eat foods that have any of these ingredients:
  • Abalone.
  • Barnacle.
  • Krill.
  • Clams, such as cherrystone, littleneck, Pismo, and quahog.
  • Crab.
  • Crawfish, crayfish (écrevisse), crawdad.
  • Lobster, langouste, langoustine, scampi, coral, tomalley.
  • Mollusks.

What does a shellfish intolerance feel like? ›

If your mouth itches, or if you develop hives or a stomachache after eating crab, lobster or other shellfish, you may have a shellfish allergy, a condition that affects nearly 7 million Americans.

Does Zyrtec help with shellfish allergy? ›

You may take antihistamines if you only experience mild symptoms after eating shellfish. Antihistamine is a drug or substance that suppresses the effects of histamine that is released when your body comes in contact with allergens. Just remember that antihistamines are not effective for severe allergic reactions.

What protein causes shellfish allergy? ›

Tropomyosin (TM) is the major allergenic protein across all edible crustacean and mollusk species. More than 60 % of shellfish allergic patients are sensitized and react to TM, often leading to severe systemic reactions.

How do you desensitize a shellfish allergy? ›

Shellfish Allergy Treatment with Oral Immunotherapy

The goal of oral immunotherapy is to continually expose the patient to increasing amounts of an allergen. As OIT progresses, the body is gradually desensitized and learns to adapt.

Does Worcestershire sauce have shellfish? ›

Shellfish can be an ingredient in some common sauces and condiments, such as soy sauce and Worcestershire sauce, so it is still important to read food labels to ensure safety. Shellfish is sometimes used as an ingredient in fish products, so specifically check these labels for shellfish.

What is a delayed reaction to shellfish? ›

IgE mediated reactions typically include immediate symptoms, such as urticaria, angioedema, dyspnea and, in some cases, anaphylaxis. There are, however, some patients who are able to consume shellfish, but later experience gastrointestinal symptoms with vomiting, abdominal cramping and diarrhea.

What to do after shellfish allergic reaction? ›

An anaphylactic reaction to shellfish is a medical emergency. Anaphylaxis requires immediate treatment with an epinephrine (adrenaline) injection and a follow-up trip to the emergency room. If anaphylaxis isn't treated right away, it can be fatal.

Can you take prednisone for shellfish allergy? ›

Treatment for accidental ingestion of shellfish products by allergic individuals varies depending on the sensitivity of the person. An antihistamine such as diphenhydramine may be prescribed. Sometimes prednisone will be prescribed to prevent a possible late phase Type I hypersensitivity reaction.

How do you clean shellfish allergy? ›

Run contaminated pots, pans, and utensils through a normal dishwasher cycle or wash them by hand with hot, soapy water and scrub the surfaces thoroughly. Use a sponge, scouring pad, or dish rag that has not come into contact with the allergen. Rinse and dry thoroughly with a clean towel.

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